Clinical significance of PCT,D-dimer,HCT and arterial blood gas analysis in patients of acute exacerbation chronic obstructive pulmonary disease with pulmonary arterial hypertension
SHENG Yanling
LI Zhijuan
DU Xinxing
WANG Jianbing
YUAN Yadong
ZHANG Jing
Abstract：Objective To investigate the significance procalcitonin ( PCT ) , D-dimmer ( D-D ) , hematocrit value (HCT) and arterial blood gas analysis in patients of acute exacerbation chronic obstructive pulmonary disease (AECOPD) with pulmonary arterial hypertension(PAH).Methods 76 hospitalized patients of AECOPD were enrolled as AECOPD combined PAH group(PASP≥35 mmHg),and 74 hospitalized patients of AECOPD were enrolled as AECOPD without merge PAH group ( PASP﹤35 mmHg) according to their pulmonary artery systolic pressure ( PASP) checking by echocardiographic , AECOPD combined PAH group divided into three subgroups: 28 patients as mild pulmonary hypertension subgroup ( PASP 35 -50 mmHg) , 36 patients as moderate pulmonary hypertension subgroup ( PASP﹥50-70 mmHg) , 12 patients as severe pul-monary hypertension subgroup ( PASP﹥70 mmHg) , detected and compared the levels of PCT , D-D,HCT and arterial blood gas analysis of the two groups and the three subgroups;and analysis of the correlation between PASP and the various indica-tors.Results (1)ThePCT,D-D,HCT,PaCO2 of the AECOPD combined PAH group was obvious higher than those of AE-COPD without merge PAH group , the PaO2 ,SaO2 were obvious lower than those of AECOPD without merge PAH group ( t =-16.090,-19.968,45.643,6.403,9.624,9.709, P =0.000).(2) The PCT,D-dimer,HCT,PaCO2 of severe PAH sub-group was obvious higher than of moderate PAH subgroup ,the PaO2 ,SaO2 was obvious lower than of moderate PAH subgroup;The PCT,D-dimer,HCT,PaCO2 of moderate PAH subgroup was obvious higher than of mild PAH subgroup ,the PaO2 ,SaO2 was obvious lower than of mild PAH subgroup ( F =204.063,281.335,149.419,179.823,215.399,138.106, P =0.000).(3) PCT,D-dimer, HCT, PaCO2 have positive correlation with PASP ( r =0.982,0.983,0.979,0.987, P =0.000);PaO2、SaO2 have negative correlation with PASP ( r =-0.991,-0.966, P =0.000).Conclusion The PCT, D-dimer ,HCT and arteri-al blood gas analysis can better reflect the PAH severity of AECOPD .
Keywords：PCTD-dimerHCTArterial blood gas analysisAECOPDPAHPASP
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 921-924 )