Analysis on effect of Chuankezhi injection combined with salmeterol fluticasone on immune function in chronic ob-structive pulmonary disease with acute aggravating period
WANG Daofeng
Fu Jun
HE Shigui
WEN Yin
Abstract：Objective To investigate the efficacy of Chuankezhi injection combined with salmeterol fluticasone on im-mune function in patients with chronic obstructive pulmonary disease ( COPD) .Methods From June 2011 to October 2014 , 85 cases of chronic obstructive pulmonary disease with exacerbation were randomly divided into two groups , observation group (43 patients) and control group (42 cases), the observation group received Chuankezhi injection combined with salmeterol fluticasone propionate therapy , the control group received salmeterol fluticasone propionate therapy , therapeutic effect , lung function changes , inflammatory markers ( CRP, IL-8, TNF-α) and T lymphocyte subsets were compared between the two groups of patients.Results The total efficiency was 97.67%in the observation group, the control group’s total efficiency was 88.10%, the two groups showed no significant difference (χ2 =2.97, P >0.05);before treatment, patients in the 2 groups had no statistically significant difference of following indexes:forced expiratory volume in one second ( FEV1 ) , forced expira-tory volume in 1 second proportion accounted for FVC ( FEV1/FVC) , forced expiratory volume in 1 second%predicted vol-ume proportion (FEV1%) ( P >0.05), after treatment, both of observation group and the control group revealed significant-ly increased of these indexes (observation group:t =9.99,6.46,8.40,control group:t =5.15, t =3.52, t =5.44, P <0.05),and the degree of increase in the observation group were better than the control group ( t =3.79, t =2.34, t =2.46, P <0.05);before treatment, serum CRP, IL-8, TNF-αlevel revealed no difference between the two groups ( P >0.05), after treatment, both of the two groups’ indexes were significantly decreased ( P <0.05), and the observation group were better than the control group ( P <0.05);before treatment, both groups’ CD3+, CD4+, CD8+, CD4+/CD8+revealed no differ-ences ( P >0.05);after treatment, these indexes’ levels were significantly improved ( P <0.05);after treatment, in the observation group , CD3+, CD4+, CD4+/CD8+level was higher and CD 8+level were lower than the control group , the difference was statistically significance ( P <0.05).Conclusion It proved that the Chuankezhi injection combined with salmeterol flu-ticasone propionate therapy revealed definite therapeutic effect for chronic obstructive pulmonary disease , it could significant improve the lung function and immune function .
Keywords：Chuankezhi injectionSalmeterolChronic obstructive pulmonary diseaseImmune function
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 917-920 )