Effects of rosuvastatin calcium on carotid artery plaque and blood lipid of patients with transient ischemic attack

KANG Yi; MA Yu; HUANG Ying; ZHAN Qunling

doi:10.3969/j.issn.1671-6450.2015.09.009

Abstract：Objective To observe the effect of atorvastatin calcium on carotid plaque and blood lipid in patients with transient ischemic attack ( TIA) .Methods Selected 76 TIA patients as the research object , according to the random number table, they were divided into treatment group with 39 cases and control group with 37 cases.The control group was given ni-modipine and aspirin , cell diphosphate choline , low molecular weight dextran and conventional drug therapy , based on the above treatment, the treatment group also given rosuvastatin calcium 10 mg/d, for taking six months.Carotid atherosclerosis plaque and blood lipid were detected before and after treatment .The incidence and adverse reactions of cerebrovascular disea-ses were recorded after 6 months of follow-up.Results After treatment, treatment group’s carotid artery intima-media thick-ness ( IMT) became thin, plaque area was significantly reduced , TC, TG, LDL-C levels decreased obviously than before treatment ( t =3.062, t =3.641, t =3.016, t =4.019, t =2.943, P <0.05), HDL-C have no statistically significant (t =1.951, P <0.05), and in the control group before and after treatment , the index had no significant change , the differ-ence was not statistically significant ( t =0.401, t =1.009, t =0.941, t =1.038, t =1.131, t =0.491, P >0.05).In the treatment group , the carotid artery intima and plaque area , TC, TG, LDL-C level differences were statistically significant ( P <0.05).In treatment group, cerebral blood vessel disease incidence rate (10.3%) was significantly lower than that of the control group (21.6%) (χ2 =4.762, P <0.05).During the treatment, the patients in both of the two groups did not oc-cur serious adverse reactions .Conclusion Rosuvastatin calcium assisted treatment can effectively reduce the carotid athero-sclerosis plaque , reduce the incidence of blood lipid level and cerebrovascular events , it is worthy of clinical application .