The levels of inflammatory factors of t-PA and PAI-1 in serum and its significance in patients with acute cerebral in-farction
LU Bo
HAN Li
LV Zhikun
ZHANG Xiaohong
FENG Zhixia
WANG Xiaojing
XU Hui
Abstract：Objective To investigate the acute cerebral infarction serum inflammatory factor , tissue type plasminogen activator( t-PA) and rapid inhibition of the variation of the enzyme ( PAI1-) and relationship with prognosis .Methods Se-lected 100 cases of patients with acute cerebral infarction as the observation group , 100 cases of patients without acute cerebral infarction as control group .Changes of serum inflammatory factor , t-PA , PAI-1 were observed at different time of admission , after admission, and analyze its relationship with and prognosis of patients with cerebral infarction .Results The observation group patients’ IL-6 and IL-18, PAI-1 and CRP levels when admitted to hospital and 3, 7, 14 days after admission were higher than that of the control group ( P <0.05), and t-PA levels were lower than the control group ( P <0.05); observation group’s IL-6 and IL1-8, PAI-1, CRP levels on admission showed a gradual decreasing trend and showed statistically signifi -cant difference with at beginning of admission ( P <0.05 ) , and t-PA level after 3 and 7 days of admission were decreased (P <0.05), after 14 days of admission, it increased than at the beginning of the admission ( P <0.05).And serum IL-6, IL-8, and PAI-1 and CRP levels’ comparison:large infarction subgroup >median infarction subgroup >small infarction sub-group ( P <0.05);adverse prognosis subgroup >good prognosis subgroup;serum t-PA levels:large infarction subgroup <median infarction subgroup <small infarction subgroup ( P <0.05), adverse prognosis subgroup <good prognosis subgroup ( P <0.05).Concluison There were significant differences of IL-6, IL-18, PAI-1,and t-PA and CRP levels in patients with acute cerebral infarction and patients without cerebral infarction , acute cerebral infarction has certain relationship with prognosis of patients and infarct area.
Keywords：Cerebral infarctionacuteInflammatory factorsTissue type plasminogen activatorRapid enzyme inhibi-tionChange rule
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 906-909 )