Observation of clinical effect of Qiliqiangxin capsule on elderly patients with systolic heart failure

LI Zheng; QIAN Yuhong; ZHOU Jing; WANG Min; FAN Zhiyuan; ZHANG Linlin; LIANG Fenglan; SHI Junling

doi:10.3969/j.issn.1671-6450.2015.09.005

Abstract：Objective To observe the therapeutic effect of Qiliqiangxin capsule in the treatment of senile congestive heart failure .Methods Selected 196 cases of age more than or equal 65 elderly patients with systolic heart failure , they were randomly divided to observation group (116 cases) and control group (80 cases).Control group was given conventional diu-retics, angiotensin angiotensin converting enzyme inhibitor (ACEI) or vascular angiotensin II receptor blocker (ARB), and beta blockers, digitalis and nitric acid ester drug treatment .The observation group also added Qiliqiangxin capsule treatment, at the beginning and after 8 weeks treatment , liver function , renal function , myocardial enzyme , clinical curative effect , 6 mi-nutes walking test (6MWT), left ventricular shoot ejection fraction (LVEF), left ventricular diastolic end diastolic diameter (LVEDD), serum N-terminal pro brain natriuretic peptide precursor (NT-proBNP) changes were detected.Results Obser-vation group’s total efficiency was superior to the conventional treatment group (92.2%vs.83.85,χ2 =6.852, P <0.05);2 groups’ LVEF, NT-proBNP were improved than before treatment ( t =4.431, t =51.213, t =6.132, t =71.663, P <0.05), observation group’s NT-proBNP levels were decreased more significantly than control group ( P <0.05).The hepatic function , renal function , myocardial enzymes in two groups before and after the treatment ’ s difference had no statistical signif-icance ( P >0.05).Conclusion Qiliqiangxin capsule effectively improves the clinical symptoms and heart function in eld-erly patients with systolic heart failure , no drug adverse events , worthy of clinical application .