Effects of Lianhuaqingwen capsules on patients with chronic obstructive pulmonary disease and changes in TNF-α, IL-8 and IL-7
BI Zhenshui
YAN Jinghong
WANG Zhengkai
LIANG Bin
Abstract：Objective To investigate the effect of the Lianhuaqingwen capsules on the pulmonary function , blood gas index and inflammatory factor tumor necrosis factor alpha (TNF-alpha),interleukin 8 (IL-8) and IL-17 in patients with chron-ic obstructive pulmonary disease (COPD).Methods From January 2014 to February 2015, 72 cases inpatient or outpatients who received treatment for chronic obstructive pulmonary disease were enrolled .They were randomly divided into 2 groups ac-cording to the random number table , 36 cases in each group .The control group was given conventional treatment , the observa-tion group on the basis of treatment in the control group , also added Lianhuaqingwen capsules;treatment lasted for 10 days. Then observed the clinical curative effect of 2 groups of patients, lung function and blood gas index and level of TNF-α,IL-8 and IL-17 level changes were compared .Results The total efficiency of observation group was significantly higher than that of the control group (94.4%vs.72.2%,χ2 =17.71, P <0.05);after treatment, the 2 groups’ patients’ pulmonary func-tion index, forced expiratory volume in one second ( FEV1 ) , FEV1/FVC ratio ( FEV1/FVC) , blood gas indexes ( PaO2 ) , partial pressure of carbon dioxide ( PaCO2 ) , TNF-α,IL-8 and IL-17 levels were significantly improved compared with before treatment, the difference was statistically significant ( P <0.05) between the 2 groups, the observation group’s improvement was better than the control group , the difference was statistically significant ( P <0.05); the 2 groups’ pH value did not change significantly before and after treatment ( P >0.05), during treatment, 2 groups’ patients’ heart rate, blood pressure and blood urine routine , liver and kidney function were not changed significantly , no other adverse reactions were found .Con-clusion Lianhuaqingwen capsules can significantly improve the clinical efficacy of patients with chronic obstructive pulmo -nary disease ( COPD) , it can effectively inhibit the release of inflammatory cytokines , thereby reducing airway inflammatory reaction.
Keywords：Chronic obstructive pulmonary diseaseLianhuaqingwen capsulesPulmonary functionBlood gas indexInflammatory factor
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 891-894 )