Effects of Tongxinluo capsule combined with amlodipine and amiloride in the treatment of left ventricular hypertro-phy
YANG Jingxiao
TENG Jiwei
LI Xue
Abstract：Objective To compare the therapeutic effect of amlodipine +compound amiloride hydrochloride and am-lodipine +compound amiloride +Tongxinluo capsule for treating of hypertension associated with left ventricular hypertrophy . Methods Eighty-two patients with LVH were divided into conventional group ( 48 cases) , and Tongxinluo group ( 34 ca-ses), they were given routine amlodipine +compound amiloride;Tongxinluo capsule group based on the conventional thera-py, also added Tongxinluo capsule(1.14g once ,three times a day).After 6 months of treatment, cardiac structure and heart function and changes in blood pressure levels in the two groups were observed .Resutl s After treatment , conventional group and Tongxinluo group patients’ systolic blood pressure (SBP), diastolic blood pressure (DBP), inter-ventricular septum thickness ( IVST ) , left ventricular wall thickness ( LVPWT ) , left ventricular weight ( LVM ) , left ventricular mass index (LVMI) were significantly decreased compared with before treatment ( P <0.01);E /A ratio and LVEF values?were sig-nificantly increased than before treatment ( P <0.05);after treatment, between the two groups, systolic blood pressure, di-astolic blood pressure’s difference were not statistically significant ( P >0.05), but IVST [(9.60 ±2.48) min vs.(8.80 ± 1.23) min],LVPWT [(9.39 ±1.20) min vs.(8.07 ±1.40) min],LVM [(275.11 ±14.77) g vs.(271.02 ±16.25) g],LVMI[( 1509.9 ±7 .35) g /m2 vs.(147.02 ±8.88) g/m2 ],E/A (0.75 ±0.18 vs.0.78 ±0.24), LVEF [(65.28 ± 3.15)%vs .(66.32 ±3.12)%]’ s differences in the 2 groups were statistically significant ( P <0.05 ), the Tongxinluo group improved more obviously .Conclusion Tongxinl uo capsule combined with amlodipine +compound amiloride hydro-chloride can increase left ventricular ejection fraction , improving heart function , so as to delay ando/r reverse left ventricular hypertrophy .
Keywords：HypertensionLeft ventricular hypertrophyAmlodipineCompound amiloride hydrochlorideTongxinluo capsuleCardiac structureHeart function
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 881-883,887 )