Effects and changes in serum CRP, TNF-α, IL-6 and urinary NAG, Alb of hemo-perfusion and hemodialysis in chil-dren with severe allergic purpura
HUANG Yongming
MO Yuntao
HUANG Shaoyi
Abstract：Objective To observe the blood perfusion flow ( HP) combined with hemodialysis ( HD) for treatment of children with severe Henoch-Schonlein purpura ( HSP) , and to investigate its effect on the level of serum C-reactive protein (CRP) and tumor necrosis factor alpha (TNF-α), interleukin-6 (IL-6) and urinary N acetyl beta D amino glucoside enzyme (NAG), albumin (Alb). Methods From November 2012 to December 2014, 72 cases of pediatric severe HSP inpatient were enrolled, they were divided into the observation group and the control group according to random number table method, 36 cases in each group. All patients of the two groups were treated with fasting, spasmolysis, hemostasis, anti-infection and maintain electrolyte balance etc. , control group with prednisolone, glucose acid calcium, loratadine, and low molecular weight heparin calcium routine treatment;the observation group on the basis of the treatment in the control group, HP and HD com-bined treatment were used, the courses of treatment in the two groups were 2 weeks. Improvement of the clinical symptoms be-fore and after treatment in two groups of children were observed respectively, enzyme linked immunosorbent assay ( ELISA) was used for the detection of serum CRP, TNF-α, IL-6 and NAG, Alb changes. Results After treatment, the observation group’ s skin rash subsided time, abdominal pain, joint swelling and pain relief time and hematuria, proteinuria reducing time were significantly shorter than control group ( P <0. 05);after treatment, serum CRP, TNF-αand IL-6 levels and urinary NAG and the levels of Alb were obviously decreased in both of the two groups ( P <0. 05), and the observation group decreased more significantly than that of the control group ( P <0. 05);observation group had 4 cases of children with different degrees of nau-sea, vomiting, and blood pressure during treatment, they were given symptomatic treatment and released, both of the 2 groups of children revealed good tolerance during treatment. Conclusion HP with HD for treatment of HSP can rapidly relieve clinical symptoms, relieve the inflammatory reaction, reduce urinary NAG and Alb levels and improve the clinical efficacy.
Keywords：Allergic purpurasevereHemoperfusionHemodialysisInflammatory factors
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 835-837,841 )