The correlation between nailfold microcirculation and clinical manifestation in patients with systemic lupus erythema-tosus
ZHOU Xiaoqiang
ZHAO Xiaoling
HUANG Lianji
GUO Shuqing
CHEN Gangmei
Abstract：Objective To investigate the relationship between microcirculation and clinical manifestations in patients with systemic lupus erythematosus (SLE). Methods From January 2011 to December 2014, 53 SLE patients were enrolled as the observation group, 50 cases of healthy volunteers over the same period enrolled as the healthy control group, all selected subjects underwent microcirculation inspection, microcirculation points difference were compared between the two groups;clinical manifestations of SLE patients were recorded, and compared microcirculation Points difference in patients with and without interstitial lung disease ( ILD ) , pulmonary arterial hypertension ( PAH ) , Raynaud 's phenomenon ( RP ) and skin rash;recorded the clinical parameters in patients with SLE, observed correlation between these indexes and nailfold microcir-culation. Results Compared with the healthy control group, the observation group’ s integral nail fold microcirculation mor-phology, flow pattern points, loop circumference and total score were significantly increased ( t =12. 992, t =11. 410, t =7. 926, t =12. 233, P <0. 05);nailfold microcirculation morphology score, integral flow pattern, loop circumference and to-tal score in ILD and PAH in SLE patients with and without ILD and PAH did not show statistically significant difference ( P >0. 05);microcirculation morphology score, integral flow pattern, loop circumference and total score in SLE patients with RP was significantly higher than that of SLE patients without RP ( t =4. 602, t =3. 981, t =4. 244, t =3. 099, P <0. 05);SLE patients with rash’ s microcirculation morphology and total score was significantly higher than that of SLE patients without rash ( t =3. 794, t =2. 865, P <0. 05), flow pattern points and loop points’ difference was not statistically significant ( t =1. 413, t =0. 617, P >0. 05); SLE patients’ microcirculation total score was positively correlated with age ( r =0. 852, P < 0. 05), and had no correlation with C3, C4, CRP, ESR, PLT, WBC, IgG, and urinary protein. Conclusion It demon-strated that the SLE patients had a certain degree of microcirculation abnormalities,aggravate the degree of abnormality of micro-circulation associated with ILD, PAH, RP and rash, so the microcirculation examination can help to observe the progression of the disease.
Keywords：Systemic lupus erythematosusNailfold microcirculationClinical manifestationsClinical index
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 821-824 )