Correlation of hyperthyroidism with disturbance of carbohydrate metabolism and its impact on insulin sensitivity
JIANG Guoliang
WANG Ping
Abstract：Objective To investigate the changes of glucose metabolism and the effect of hyperthyroidism on insulin sensitivity in patients with hyperthyroidism. Methods From January 2012 to December 2014, 68 patients with hyperthyroi-dism were enrolled, according to oral glucose tolerance test ( OGTT) , the patients were divided into glucose tolerance impair-ment group (IGT group, n =32) and normal glucose tolerance group (NGT group, n =36), and compared with healthy con-trols (NC group, n =30), the fasting plasma glucose (FPG), postprandial 2 h blood glucose (2 h PG), free three iodine thyroid original ammonia acid ( FT3 ) , free thyroxine( FT4 ) , thyroid stimulating hormone ( TSH) , and calculate the insulin re-sistance index ( HOMA-IR) and insulin sensitivity index ( HOMA-IS) were detected. Results IGT group’ s FPG and OGTT at each time point’ s glucose load were significantly higher than those of the NGT group and NC group ( F =63. 65, F=95. 84, F =71. 36, F =137. 48, P <0. 05), NGT group’s OGTT at 2h, 3h glucose load was significantly higher than that of NC group ( P <0. 05), FPG, OGTT 1-hour glucose load had no significant difference from NC groups ( P >0. 05);IGT group HOMA-IR was significantly higher than that in NGT group, NC group, HOMA-IS significantly reduced ( F =52. 32, F =13. 71, P <0. 05). Compared with before treatment, after treatment, hyperthyroidism patients FT3, FT4, FPG, 2 h PG and HOMA-IR were significantly decreased,TSH,HOMA-IS significantly increased ( P <0. 05). Pearson correlation analysis showed that HOMA-IR and TSH were negative correlated ( r = -0. 568, P <0. 05), positively correlated with 2 HPG ( r =0. 625, P <0. 05), HOMA IS and TSH was positively correlated ( r = 0. 554, P <0. 05), and were negative correlated with 2h PG ( r = -0. 487, P <0. 05). Conclusion Hyperthyroidism patients often accompanied with disorders of glucose metabolism,insulin sensitivity decreased,in the treatment of hyperthyroidism,strengthen the monitoring of blood sugar and prevent complications occurred are necessary.
Keywords：HyperthyroidismDisorder of glucose metabolismInsulin sensitivity indexImpaired glucose tolerance
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 818-820 )