The relationships between serum level of VEGF,β2-MG, TRAF6, Bcl-6 in diffuse large B cell lymphoma with the prognosis
HE Jiqiong
LI Yaqiong
YANG Lihua
QIAO Aiguo
Abstract：Objective To observe the effect of serum vascular endothelial growth factor ( VEGF) , beta 2 microglobu-lin(β2-MG), TNF receptor associated factor 6 (TRAF6) and B cell lymphoma factor-6 (Bcl-6) level in diffuse large B cell lymphoma ( DLBCL) patients’ prognosis.Methods From 2012 April to 2014 April, 51 cases of diffuse large B cell lympho-ma were enrolled, records of different gender, age, whether involved the mediastinum, whether combined with group B symp-toms, lactate dehydrogenase level and the effect of different treatments were recorded, analysis serum vascular endothelial growth factor ( VEGF) ,β2-MG, TRAF6 and Bcl-2 serum level on the prognosis of the patients.Results In the 51 cases of DLBCL patients, high level of VEGF were found in 25 cases,β2-MG high level in 39 cases, TRAF6 was positive in 11 cases, Bcl-6 were positive in 8 cases.Different gender, different age, mediastinal invasion, with B symptoms, clinical stage, lactate dehydrogenase increased or not had no relation with the number of patient with serum VEGF andβ2-MG, TRAF6, Bcl-6 high level (all P >0.05), but β2-MG, TRAF6, Bcl-6 high level/positive and low level/(negative) therapeutic effect difference has statistical significance (χ2 =10.455,χ2 =7.913,χ2 =5.004, P =0.001, P =0.005, P =0.025).Low risk group’s VEGF,β2-MG, TRAF6 and Bcl-6 were (446.31 ±38.82) ng/ml, (194 3.15 ±178.28) ng/ml, (1.27 ±0.60) ng/ml, (13.68 ±7.32) ng/ml, respectively, the high-risk group were (482.31 ±37.71) ng/ml, (2 128.32 ±243.12) ng/ml, (1.72 ±0.83) ng/ml, (21.93 ±6.85) ng/ml,respectively, 2 groups’ difference has statistical significance ( t =3.348, t=3.040, t =2.174, t =4.150, P =0.002, P =0.004, P =0.035, P =0.000).Conclusion The serum VEGF,β2-MG, TRAF6, Bcl-6 level in diffuse large B cell lymphoma patients are helpful to judge the prognosis and to improve the treat-ment of DLBCL and determine individualized treatment plan, which has important guiding significance.
Keywords：Diffuse large B cell lymphomaEndothelial growth factorBeta 2 microglobulinTNF receptor associated factor 6Bcl-6Prognosis
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 708-711 )