Correlation study between Parkinson’ s disease and REM sleep behavior
LIU Shu
SU Qingjie
HUANG Ruping
CHEN Cong
WANG Desheng
LI Li
Abstract：Objective To observe the occurrence rate, onset time and electrophysiological characteristics of REM sleep behavior disorder ( RBD) in patients with Parkinson's disease, and to explore the relationship between RBD and Parkin-son's disease.Methods According to previous survey of sleep quality and guide polysomnography( PSG) to observe the char-acteristics of sleep disorder.(1) Subjective sleep investigation: Parkinson's disease ( PD) group of 60 cases, age matched healthy control group with 60 cases, asking sleep history to understand the proportion of RBD and time.(2) PSG:120 sub-jects received PSG monitoring for 2 consecutive nights.To analyze the PSG characteristics of RBD patients with Parkinson's disease.Results The PD combined with RBD was 75.0%(45/60), which were significantly higher than those in healthy control group of 40.0%(24/60),the proportion of patients with RBD early than clinical symptom of PD was 40.0% (18/45).The PSG test showed that the main PSG characteristics in PD with RBD: Rapid eye movement (REM) sleep period, muscle loss of achalasia and systemic activity of skeletal muscle were increased, compared with the healthy control group, the difference were statistically significant ( t =23.2, t =20.6, P <0.01).Conclusion The RBD rate is high in PD patients, part of RBD precede the classical motor symptoms appearance, which suggesting that RBD maybe the early manifestations of PD.The PSG is an diagnostic index of PD associated with RBD.
Keywords：Parkinson’ s deseaseRapid eye movement sleep behavior disorderPolysomnography
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 689-691 )