Clinical observation of self developed Zhenjinganshen decoction combined with mirtazapine tablets in 30 cases suf- fered from anxious and depressive state with intractable insomnia
JIANG Guoqing
SUN Xiaofeng
ZHANG Wenjing
ZHANG Chengqi
WANG Fenghui
GUO Xiao
QIU Bei
Abstract：Objective To observe the therapeutic effect of self developed Zhenjinganshen decoction combined with mirtazapine in the treatment of intractable insomnia with anxiety and depression.Methods Sixty cases of anxiety and depres-sion with intractable insomnia patients were randomly divided into 2 groups, the study group of 30 cases were treated with self developed Zhenjinganshen decoction combined with mirtazapine;30 cases in the control group were only treated with mirtazap-ine.Before treatment and 2 weeks, 4 weeks and 8 weeks after the treatment, Hamilton Depression table ( HAMD) , Hamilton Anxiety Scale (HAMA) and Pittsburgh sleep quality index (PSQI) were performed in both of the two groups, observed the two groups’ score and reduce rate of change before and after treatment, and after treatment, adverse reactions weight table ( TESS) score changes, the clinical effect of self developed Zhenjinganshen decoction combined with mirtazapine in the treat-ment of anxiety and depression with intractable insomnia were assessed.Results Compared with before treatment, the two groups after two weeks, four weeks and eight weeks of treatment, HAMD, HAMA and PSQI scores were decreased, the differ-ence was statistically significant (HAMD:F =151.89, P <0.05, F =80.50, P <0.05;HAMA:F =169.61, P <0.05, F =69.34, P <0.05;PSQI:F =108.96, P <0.05, F =50.64, P <0.05);compared with the control group, in the tudy group after two weeks, four weeks and eight weeks treatment, HAMD, HAMA and PSQI scores were decreased, the difference was statistically significant (at 2 weeks, HAMD:t =5.33, P <0.05;HAMA:t =3.47, P <0.05;PSQI:t =4.33, P <0.05;at 4 weeks, HAMD:t =5.11, P <0.05;HAMA:t =4.98, P <0.05;PSQI:t =3.16, P <0.05;at 8 weeks, HAMD:t =2.34, P <0.05;HAMA:t =4.13, P <0.05; PSQI:t =3.01, P <0.05); After 8 weeks of treat-ment, the total efficiency of the study group was 93.3%,in the control group the total effective rate was 70.0%, with total ef-ficiency’s difference between the two groups was statistically significant (χ2 =5.46, P <0.05), study group was better than the control group;2 group after 8 weeks treatment, the TESS scores were significantly different between them ( t =-2.63, P <0.05).2 groups’ major adverse reactions included body mass increased, drowsiness, dizziness, gastrointestinal discom-fort, adverse reactions in study group at 4 weeks, 8 weeks were 15 cases (50.0%), 5 cases (1.7%), adverse reactions in the control group at four weeks, eight weeks were 27 cases (90.0%), 12 cases (40.0%), the two groups showed statistical-ly significant differences in the same period (4 weeks:χ2 =11.43, P <0.05;8 week,χ2 =4.02, P <0.05) .Conclusion It proved that the self developed Zhenjinganshen decoction combined with mirtazapine could significantly improve the state of anxiety and depression in patients with refractory insomnia with less adverse reactions and good clinical effects.
Keywords：Decoction of Chinese medicineAnxious and depressive stateIntractable insomniaIntegrated tradition-al Chinese and western therapy
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 682-685 )