Study on the relationship between lacunar infarction and cognitive impairment
LI Honglian
JIA Jundong
YIN Xue
YUE Weidong
Abstract：Objective To explore the relationship between lacunar infarction( LI) and cognitive function.Methods 94 cases of hospitalized patients with LI were collected, according to the MR examination’ s number of basal ganglia and thala-mus’ LI, patients were divided into 3 groups, 1-3 lesions was mild group, 4-6 lesions was moderate group,≥7 lesions was severe group.Select another group of elderly people with normal MR as the control group.The Montreal cognitive assessment scale table ( MoCA) ( Beijing version) and Alzheimer's disease cognitive table ( ADAS-Cog) as a cognitive assessment tool to observe different LI group whether has decline in cognitive function.Results Compared with the control group, mild and moderate LI groups had no significantly decrease of cognitive function ( P >0.05) , severe LI group’ s cognitive function were decreased significantly ( P <0.05);MoCA scores decreased with the rising of LI group level.In the ADAS-Cog table score, compared with the control group, mild and moderate LI groups ’ cognitive function had no decreased significantly ( P >0.05), severe LI groups’ cognitive function decreased significantly ( P <0.05);the total score increased with the rising of LI grouping level.The more serious of the LI of the basal ganglia and the thalamus in the thalamus, the more obvious of the decrease of the cognitive function.Conclusion Basal ganglia and thalamus area multiple LI influence patients cognitive func-tion, cognitive domain is mainly manifested in the execution of the function, abstract thinking, language function, attention, orientation, and influence on memory function is not obvious.
Keywords：Lacunar infarctionCognitive functionBasal gangliaThalamusExecutive function
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 679-681 )