Clinical efficacy of PA-MSHA injection in treatment of malignant pleural effusion

DU Xinchao; WU Kun; ZHU Haiyong; LI Yong

doi:10.3969/j.issn.1671-6450.2015.06.013

Abstract：Objective To observe the clinical curative effect of pseudomonas aeruginosa injection ( PA-MSHA) in thetreatmentofmalignantpleuraleffusion.Methods 60patientswithmalignantpleuraleffusionwererandomlydividedinto treatment group and control group, 30 cases in each group.The treatment group was treated with intrapleural injection of PA-MSHA;the control group was treated with intrapleural injection of cisplatin.After 30 day’s treatment, clinical curative effect, Karnofsky score and adverse reaction were compared between the 2 groups.Results In the treatment group, the total efficien-cy was 83.3%(25/30) and the control group’s total efficiency was 53.3% (16/30), the treatment group total efficiency was higher than that of the control group (χ2 =6.24, P <0.05); in treatment group, after treatment, Karnofsky score was significantly higher than that before treatment [(53.1 ±6.9) vs.(67.9 ±2.3), t =11.15, P <0.05],the control group af-ter treatment, Karnofsky score was higher than before treatment (51.5 ±9.5) vs.(60.1 ±3.2), ( t =4.70, P <0.05), in the treatment group after treatment, Karnofsky score was significantly higher than that of control group, the difference was sta-tistically significant ( t =10.84, P <0.05).The treatment group’s Karnofsky improvement rate was 80%, which was higher than the control group’s 53.3%(χ2 =4.80, P <0.05).Treatment group’s incidence of adverse reactions was 46.7%(14/30), the control group was 76.7%(23/30), and the adverse reaction occurred rate in the treatment group was lower than the control group (χ2 =4.34, P <0.05).Conclusion PA-MSHA in treatment of malignant pleural effusion can significantly im-prove the clinical efficiency and improve the quality of life of patients, and adverse reaction was less, which is worthy of clini-cal application.