Expression and clinical significance of ER, PR and PCNA in differentiated thyroid cancer
HUANG Xia
LIU Jingli
WU Jiansong
LI Xiangrong
CHEN Liang
Abstract：Objective To investgate the expression of estrogen receptor( ER) ,progesterone recepter( PR) and prolif-eratiing cell nuclear antigen( PCNA) using immunohistochemistry in every specimen, analyzed the clinical significance of the three indexes.Methods From March 2012 to March 2013 in the hospital for treatment of 105 patients with thyroid related dis-eases as the research object.33 patients with papillary carcinoma of thyroid cancer.24 patients with thyroid follicular carcino-ma.24 cases of thyroid adenoma.24 patients with nodular goiter.Using immunohistochemical method determination of ER and PR in all specimens, and the expression of PCNA, analysis the three parameter’ s clinical significance.Results In papil-lary thyroid carcinoma, <45 years old patients’ expression of ER positive rate was significantly higher than that of more than or equal to 45 years old patients(χ2 =3.945,χ2 =3.688, P <0.05), lymph node metastasis of ER positive expression rate was also significantly higher than those without lymph node metastasis; thyroid follicular carcinoma, lymph node metastasis’ ER positive expression rate were lower than that in the lymph node metastasis (χ2 =4.232, P <0.05).The PR positive ex-pression of papillary thyroid carcinoma without lymph node metastasis was significantly higher than that of lymph node metasta-sis(χ2 =3.861, P <0.05).Thyroid follicular carcinoma with lymph node metastasis of PCNA positive expression rate was significantly higher than that without lymph node metastasis (χ2 =4.231, P <0.05).Papillary thyroid carcinoma with ER and PCNA positive expression rate was significantly higher than that of nodular goiter and thyroid adenoma (χ2 =6.561、8.412、4.520、7.695, P <0.05).The positive expression of PR in papillary thyroid carcinoma was significantly higher than that of nodular goiter patients (χ2 =5.519, P <0.05).Papillary thyroid carcinoma of ER, PR and PCNA staining positive classification was significantly higher than that of nodular goiter and thyroid adenoma (χ2 =4.520,χ2 =5.988,χ2 =3.256,χ2 =3.635,χ2 =3.968,χ2 =5.509, P <0.05).Spearman correlation showed that the thyroid papillary carcinoma and follic-ular thyroid carcinoma, ER and PR were positively correlated ( r =0.459, r =0.618, P <0.05) .In papillary thyroid carci-noma, PCNA protein expression were negatively correlated with ER and PR ( r =-0.456, r =-0.442, P <0.05).In thy-roid follicular carcinoma, the expression of PCNA protein was negatively correlated with ER ( r =-0.635, P <0.05).Con-clusion The differentiated thyroid carcinoma in ER, PR, PCNA expression positive rate was significantly higher than that in benign thyroid tumor tissues, the expressions of ER, PR, PCNA play an important role in differentiated thyroid cancer onset and development, and there were correlation among the three indexes.Therefore, combined detection of ER, PR, PCNA in the diagnosis and treatment of differentiated thyroid cancer has important value.
Keywords：Differentiated thyroid cancerEstrogen receptorProgesterone receptorProliferating cell nuclear anti-genExpressionValue
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 586-589 )