The effect of early intravenous beta blockers on prognosis in patients with acute myocardial infarction:a Meta analy-sis
WANG Danning
CHEN Pengfei
HUANG Ying
CHEN Kan
WANG Lei
LIAO Dening
Abstract：Objective To evaluate the effect of early intravenous beta blockers on prognosis in patients with acute myocardial infarction( AMI) .Methods Searched on PubMed, Embase, Cochrane library, CNKI, Wanfang Data,VIP journal resources integration service platform, the Chinese biomedical literature database, collected and compared AMI reperfusion pa-tients received early intravenous beta blockers ( test group) and does not use beta blockers or placebo ( control group) to study the impact on prognosis.Main outcome measurements included short-term and long-term all-cause mortality and malignant ar-rhythmia,myocardialinfarction,cardiogenicshockincidence.UsingtheRevman5.2softwaretoextractthedata.Results 8 studies with 48 367 patients were enrolled.Meta-analysis showed that, compared to the control group, experimental group’ s myocardial infarction malignant ventricular arrhythmia incidence decreased ( OR=0.83, 95% CI 0.75-0.93, P =0.000 9);cardiogenic shock, heart failure incidence increased (OR=1.29, 95% CI 1.18 -1.41, P <0.01);2 groups’ all-cause mortality, re-myocardial infarction, ischemic adverse events rates were showed no statistically significant ( OR=0.98, 95%CI 0.92-1.05, P =0.63;OR=0.95, 95%CI 0.88-1.03, P =0.21).Conclusion In early stage of AMI, intra-venous beta blockers can reduce infarction related malignant ventricular arrhythmia rate, but also increase the risk of heart fail-ure, cardiogenic shock, there is no obvious benefit in the aspects of decreasing mortality rate.
Keywords：Myocardial infarctionacuteBeta blockerMeta analysis
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 511-515 )