Expression of serum IL-6, IFN-γ, TNF-α, NKG2D in patients with lung cancer and its clinical significance

ZHANG Jing; ZHANG Zhenan

doi:10.3969/j.issn.1671-6450.2015.05.012

Abstract：Objective To investigate the expression of serum levels of IL-6, IFN-γ, TNF-α, NKG2D in patients with lung cancer and its clinical significance.Methods From January 2011 to December 2013, 52 cases of lung cancer patients were selected as the research object.50 cases of healthy subjects were selected as control group.Serum IL-6, IFN-γ, TNF-α, NKG2D levels were detected, and the serum IL-6, IFN-γ, TNF-α, NKG2D levels and age, smoking history, course of the disease, lung cancer staging, pathological type and BMI were collected for correlation analysis.Results Lung cancer group serum IFN-γ, NKG2D level were lower than those in the healthy control group with significant difference ( t =10.098, t =8.726, P <0.01); Different types of lung cancer’ s serum IL-6, IFN-γ,TNF-α,indexes of NKG2D level had no obvious difference ( t =1.272, t =0.098, t =0.978, t =1.079, P >0.05);Serum IL-2, IFN-γ,TNF-α,NKG2D levels in differ-ent lung cancer stage had significant differences ( F =6.762, F =9.218, F =10.977, F =11.033, P <0.01).The lung cancer group, serum IL-6,TNF-αlevel higher than the healthy control group, with significant difference ( P <0.01); With the increase of lung cancer stage, serum IFN-γ, NKG2D levels were decreased, and the differences between stage 4 and 3 were significant ( P <0.01);With the increase of lung cancer stage, serum IL-6, TNF-αlevel is increased, and the differ-ences between stage 4 and 3 were significant ( P <0.01);Serum IFN-γ, NKG2D and negatively correlated with lung cancer stage ( r =-0.251, r =-0.315, P <0.05), serum IL-6, TNF-αwas positively associated with lung cancer stage ( r =0.402, r =0.298, P <0.05).Serum IL-6, NKG2D expression was positively correlated ( r =-0.308, P <0.05), IFN-γand TNF-αwere negatively correlated ( r =-0.307, P <0.05).Conclusion The expression of the IFN-γ, NKG2D re-vealed lower expression in serum of patients with lung cancer, and IL-6, TNF-αwere increased in patients with lung cancer, IL-6, IFN-γ, TNF-α, NKG2D are closely associated with lung cancer and its progress.