Tripterygium wilfordii glycosides in treatment of idiopathic membranous nephropathy and effect on the coagulation fibrinolytic system and endothelial cell function
FENG Siping
WANG Zhiguo
AN Wenjun
ZHANG Xijun
Abstract：Objective To observe the effect of tripterygium glycosides tablet adjuvant treatment of idiopathic membra-nous nephropathy ( IMN) and the impact on blood coagulation fibrinolysis system and endothelial cells’ function.Methods From 2012 June to 2014 July, 240 IMN patients were randomly divided into 2 groups according to hospitalization order,120 cases in the control group received small dose of hormone and other comprehensive treatment, the observation group of 120 ca-ses based on the treatment of control group, also received tripterygium wilfordii glycoside tablet (2 mg by oral,3 times/d). Follow up of 6 months, and the adverse reactions of 2 groups were observed and the curative effect of 2 groups were compared, 24 h urine protein, serum albumin (Alb), total cholesterol (TC) and three acyl glycerides (TG), alanine aminotransferase ( ALT) , aspartate aminotransferase ( AST) levels were measured, and before and after treatment, plasma tissue plasminogen activator ( t-PA) , I type plasminogen activator inhibitor ( PAI-I ) and endothelin-1 ( ET-1 ) level were checked in the 2 groups.Results Total effective rate of observation group was 87.50%, which was significantly higher than that of control group’s 54.17%(χ2 =32.27, P <0.05).After treatment, 24 h urine protein TC, TG in the 2 groups were significantly lower than that before treatment, while Alb was higher than that before treatment;observation group were better than those in control group ( P <0.05).The observation group after treatment, PAI-I and ET-1 were decreased, t-PA was increased sig-nificantly ( P <0.05), before and after treatment in control group, t-PA, PAI-I, ET-1 did not show significant differences (P >0.05), after treatment, the 2 groups also showed statistically significant differences ( P <0.05).Conclusion Tripterygium wilfordii glycosides tablet adjuvant therapy for IMN is safe and effective, and can improve the coagulation fibri-nolysis system and protect endothelial cell function.
Keywords：Idiopathic membranous nephropathyTripterygium wilfordiiCurative effectCoagulation fibrindytic sys-temEndothelial cell function
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 472-475 )