Polymorphism of CD36 gene and cardiovascular risk factors in patients with coronary artery disease

ZHAO Ning; ZHANG Huijie; WANG Jianchang

doi:10.3969/j.issn.1671-6450.2015.05.004

Abstract：Objective To investigate the relationship between CD36 gene polymorphism and coronary artery disease ( CAD) ’ s risk factors.Methods 90 CAD patients aged <60 were collected, hemoglobin ( Hb) , white blood cell ( WBC) , mononuclear cells ( M) , basophils ( B) ,fasting blood glucose ( FPG) , high sensitive C reactive protein ( hs-CRP) , total cho-lesterol ( TC) , high density lipoprotein cholesterol ( HDL-C) and low density lipoprotein cholesterol ( LDL-C) and triglyceride (TG),apolipoprotein A1(ApoA1), ApoB and lipoprotein (α) [Lp (α)]were detected. At the same time recording quality, systolic pressure, diastolic pressure volume of patients, and calculated the body mass index and mean arterial pressure.Using denaturing high performance liquid chromatography to analyze intron fragment containing exon 4 and exon 5’ s amplicon, ana-lyzed the correlation between the genotype and the variables.Results There are two kinds of polymorphism of CD36 gene:IVS3-6 T/C (rs3173798) and IVS4-10 G/A (rs3211892).The IVS3-6 TC/polymorphism of C alleles was correlated with o -besity,diabetes, serum Lp ( a) concentration decreases and the early age onset of myocardial infarction .While the number of IV4S-10 G/A polymorphism of A alleles was related to late myocardial infarction and increase of white blood cell .Conclusion CD36’ s IVS3-6 C allele was correlated with the risk factors of cardiovascular disease ( such as hs-CRP, BMI and type 2 di-abetes mellitus) , and correlated with early age onset of myocardial infarction;while the IVS4-10 A allele was correlated with late age onset of myocardial infarction.The role of CD36 polymorphism in CAD is still needs further research.