Effect of high dose atorvastatin on endothelial function in patients with acute myocardial infarction after percutaneous coronary intervention
XIE Jinhong
CHEN Yushan
LUO Minghua
WANG He
QIU Chengjie
DONG Wenjie
Abstract：Objective To observe the effects of high dose atorvastatin on enodthelin-1 ( ET-1) , nitric oxide ( NO) , soluble intercellular adhesion molecule 1 (slCAM-1) and high sensitive C reactive protein (hs-CRP), blood lipid in acute myocardial infarction ( AMI ) patients with percutnaeous coronary intervention ( PCI ) .Methods From September 2012 to September 2014, 113 patients with AMI after PCI were randomly divided into control group (58 cases) and treatment group (55 cases) , 2 groups were treated with routine anticoagulation, antiplatelet, reverse ventricular remodeling drugs, control group based on the conventional therapy added atorvastatin 20 mg orally, the patients in the treatment group were treated with atorvastatin 40 mg orally on the basis of conventional therapy.2 groups of patients at the immediate and after 1, 30 d admis-sion, peripheral blood NO, ET-1, slCAM-1, hs-CRP level and blood lipid level were determined.Observed the effect of dif-ferent doses of atorvastatin on inflammatory markers, endothelial function and blood lipid.Results Compared with before treatment, after 30 d’ s treatment, ET-1, slCAM-1, hs-CRP and lipid levels were decreased in both of the 2 groups ( P <0.05), level of NO were elevated.And at 30 d’s treatment, these indices in the treatment group were more significant than the control group ( P <0.05).No statistically significant differences of adverse reactions were found in the 2 groups ( P >0.05).Conclusion Atorvastatin can decrease the inflammatory reaction of reperfusion after PCI in AMI patients, improve endothelial function, high dose of atorvastatin has more obvious effect than the conventional dose and no obvious adverse reac-tion were found.
Keywords：Myocardial infarctionacutePercutaneous coronary interventionEndothelial functionAtorvastatin
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 445-448 )