Effect of atorvastain on nuclear factor kappa B activity in patients with diabetse mellitus combined coronary hae rt disease
HUANG Gairong
ZHANG Qian
DUAN Mingqin
XU Xianjing
CAO Xuanhc ao
SANG Tiantian
Abstract：Objective To investigate the effect of atorvastain on nuclear factor kappa B activity in patients with dia-betes mellitus (DM) combined coronary heart disease (CHD).Methods There were one hundred and fifty patients, thirty of them were divided into control group ( group A) , sixty of them were divided into coronary heart disease group ( group B) , and the last sixty of them were divided into diabetes mellitus combined coronary heart disease group (group C).The patients of group C and group B were randomly divided into two subgroups:10 mg of atorvastatin group and 40 mg of atorvastatin group. The activity of nuclear factor kappa B and level of IL-6, hs-CRP were tested by flow cytometry method, enzyme linked immu-nosorbent method and latex enhanced transmission cells immune turbidimetric method.Results ( 1 ) Compared with group A, the level of IL-6, hs-CRP and activity of NF-κB in group B and group C were increased.After treated with atorvastain,the level of IL-6,hs-CRP and activity of NF-κB were decreased,and 40mg atorvastain subgroup declined more significantly ( P <0.05 or P <0.01).(2) There was positive correlation between NF-κB and IL-6, and between NF-κB and hs CRP ( r =0.550, r =0.675,P <0.01) .Conclusion The activity of NF-κB in patients with diabetes mellitus and coronary heart di-sease was higher, being treated with high dose of atorvastatin can significantly inhibit the inflammatory response in vivo.
Keywords：Coronary heart diseaseDiabetes mellitusNuclear factor Kappa BAtorvastain
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 441-444 )