Clinical effect of mycophenolate mofetil and tripterygium glycosides on refractory nephrotic syndrome and the influe-nce of renal function
CHEN Hui
CAO Fang
LI Xiong
YUAN Feiyuan
Abstract：Objective To observe the effect of mycophenolate mofetil and tripterygium glycosides on the renal func-tion of refractory nephrotic syndrome.Methods From June 2010 to August 2013, 82 cases of refractory nephrotic syndrome patients were randomly divided into control group (40 cases) and observation group (42 cases).Control group were treated with mycophenolate mofetil therapy, patients in the observation group was treated with mycophenolate mofetil combined with tripterygium glycosides.Clinical therapeutic effect and renal function (24 h urinary protein, blood urea nitrogen, serum albu-min, serum creatinine) changes were compared between the 2 groups.Results The total efficiency of the observation group was 73.8%(31/42), which was higher than that of the control group of 47.5% (19/40) (χ2 =5.960, P <0.05);24 h urinary protein, blood urea nitrogen, serum albumin, serum creatinine were improved in both of the 2 groups than before treat-ment ( t =9.440, t =17.750, t =5.710, t =2.803, t =11.473, t =13.823, t =9.685, t =4.671, P <0.05), 24 h uri-nary protein, Alb, SCr improved more obviously in observation group ( t =3.427, t =3.099, t =2.362, P <0.05);the re-currence rate was 0 in the observation group, which was lower than that in control group of 15.8%(3/19) (χ2 =5.207, P <0.05);no significant difference of adverse reactions were found between the 2 groups (21.4%vs.27.5%,χ2 =0.410, P >0.05).Conclusion Refractory nephrotic syndrome could be treated by mycophenolate mofetil combined with tripterygium gly-cosides, the clinical effects are significant, adverse reactions are slightly.
Keywords：Refractory nephrotic syndromeMycophenolate mofetilTripterygium glycosidesRenal function
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 363-365 )