Effect of hypertriglyceridemia waist circumference phenotype and impaired fasting glucose on the incidence of diabe-tes and their corelation
GUO Yifei
LI Min
WANG Nana
LI Xuefeng
Abstract：Objective To investigate the hypertriglyceridemia waist circumference phenotype( HTGW) and impaired fasting glucose ( IFG) ’ s independent effects on the pathogenesis of diabetes and correlation.Methods The clinical data of 235 healthy people were recorded and analyzed, using Cox regression model to analyze the relationship of HTGW, IFG, high waist circumference, hypertriglyceridemia ( TG) with the prevalence of diabetes mellitus, and by Cox proportional regression model to stratify the interaction between IFG and HTGW.Results In HTGW( +) and in HTGW( -) objects, compared with IGF(-) objects, IGF(+) objects had higher age, waist circumference, body mass index ( BMI) , systolic blood pres-sure, diastolic blood pressure, total cholesterol (TC), TG, fasting plasma glucose (FPG), low density lipoprotein cholesterol (LDL-C), family history of diabetes and lower high density lipoprotein cholesterol (HDL-C) ( P <0.05); after 5 years of follow-up, new onset diabetes incidence was 4.36%(90/2 066);baseline IFG(+) objects had the highest incidence during follow-up (6.06%, 58/957), HTGW( +) objects had the second incidence of diabetes (3.18%, 10/314); multivariate Cox proportional hazard regression analysis showed that diabetes risk (HR1) and 95%CI values of HTGW( +), IFG( +), high waist circumference and high TG objects were 2.25 (1.49-3.42), 3.44 (2.27-5.22), 1.54 (1.02-1.54) and 1.81 (1.19-2.74), there were statistically significant difference ( P <0.05).After adjustment of each variable, multi fac-tor Cox regression analysis showed that HTGW, IFG and high TG were still correlated with diabetes,HR2 and 95%CI were 2.05 (1.35-3.10), 3.37 (2.23-5.11) and 1.78 (1.17-2.69),with significant difference( P <0.05).But the correlation between high waist circumference and diabetes were disappeared ( P >0 !.05).Cox layered analysis results show that, com-pared with the HTGW(-) and IFG(-) objects, diabetes HR values and the 95%CI in HTGW( +) IFG( +) object was 3.07 (2.03-4.65), after adjustment of each variable, diabetes HR values and the 95%CI of HTGW(+) and IFG(+) ob-ject was 12.33 (8.14-18.68).Conclusion HTGW had independence in the role of predicting diabetes, HTGW and IFG had adding interaction to diabetes.
Keywords：Hypertriglyceridemia waist circumferenceImpaired fasting glucoseDiabetes mellitusInfluencing fac-torsCohort study
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 349-352 )