Correlation among PCI contrast agent dose and serum creatinine, estimated glomerular filtration rate, creatinine clearance rate and adverse events in short and middle time points
XIE Jianwei
ZHU Hao
HUANG Rongchong
Abstract：Objective To observe the relationship between percutaneous coronary intervention ( PCI) contrast agent dose and serum creatinine ( SCr) , glomerular filtration rate ( eGFR) and the adverse events in the short, middle time points. Methods According to the dose of contrast agent, 462 patients after PCI were divided into 2 groups, the dose <150 ml group with 103 cases (control group) and the dose of 150-300 ml group of 359 cases (observation group).Recorded the SCr, eGFR and creatinine clearance rate ( CCr) before and after the operation at 1 week, 1 month, 3 months, 9 months, also recorded contrast induced nephropathy ( CIN) incidence, re-infarction after PCI operation, main adverse cardiovascular events ( MACE) such as PCI,coronary artery bypass graft and sudden death’ s occurrence.Results There were no significant differe-nces of preoperative and postoperative SCr, eGFR and CCr in the 2 groups of patients ( P >0.05).The incidence of CIN:5 cases (4.9%) in the control group, which was lower than the observation group of 19 cases (5.3%) (χ2 =0.031, P =0.86).The incidence of MACE:13 cases (12.6%) in the control group, which was lower than the observation group of 41 cases (11.4%) (χ2 =0.112, P =0.738).eGFR is an independent risk factor for CIN (OR=0.931, 95% CI 0.910-0.952, P <0.01) .Conclusion Less than 300 ml, with increasing the dose of contrast agent, the function of kidney injury severity is not increased;the near and middle term incidence of adverse events was not affected by the dose of contrast agent.
Keywords：Contrast agentDosagePercutaneous coronary interventionGlomerular filtration rateCreatinineAd-verse events
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 338-342 )