Effect of atorvastatin combined with trimetazidine on the levels of NT-proBNP,hs-CRP, Fib and cardiac function in coronary heart diseaseANG Xiaodong, ZENG Bo, XU Chunping.Department of Cardiology, The First People’ s Hospital
W ANG Xiaodong
ZENG Bo
XU Chunping
Abstract：Objective To investigate the effects of atorvastatin combined with trimetazidine on the levels of N-termi-nal pro brain natriuretic peptide (NT-proBNP), high sensitive C-reactive protein (hs-CRP), plasma fibrinogen (Fib) and left ventricular end diastolic diameter ( LVEDD) , left ventricular ejection fraction ( LVEF) and left ventricular thickness wall thickness degree ( LVPWd) in coronary heart disease.Methods Using random number table method, 156 patients with coro-nary heart disease were divided into observation group and control group with 78 cases in each group, 2 groups of patients were taken routine treatment, the control group added trimetazidine, observation group were given atorvastatin combined with trime-tazidine treatment, treatment lasted for 30 d.Clinical efficacy and NT-proBNP, hs-CRP, Fib, LVEDD, LVEF, LVPWd were compared between the 2 groups.Results The total effective rate of observation group was 94.87%, which was higher than that of the control group of 79.49%(χ2 =3.513, P <0.05); compared with before treatment, 2 groups’ NT-proBNP,hs-CRP and Fib were significantly decreased ( P <0.05), and the observation group were more obviously than that in control group (t =3.646, t =4.013, t =2.856, P <0.05); after treatment, 2 groups of heart function were improved ( P <0.05), and the observation group’s LVEDD, LVPWd was significantly lower than those of control group ( t =2.653, t =1.978, P <0.05), LVEF was significantly higher than the control group ( t =2.374, P <0.05).Conclusion It demon-strated that the atorvastatin combined with trimetazidine can help decrease the NT-proBNP and the content of Fib, improve the cardiac function and treatment effect.
Keywords：Coronary heart diseaseAtorvastatinTrimetazidineBiochemical indexCardiac function
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 335-337,342 )