HIV related Kaposi sarcoma:report of 5 cases and review of the literature

LIU Songtao; WANG Wen; MOU Danlei; CHEN Xiaolan; LI Wei; JIANG Taiyi; ZHANG Tong

doi:10.3969/j.issn.1671-6450.2015.02.013

Abstract：Objective To investigate the clinical manifestations, diagnosis, treatment and prognosis of HIV related Kaposi sarcoma (KS). Methods From 2004 to 2014, the clinical data of 5 KS patients were retrospectively analyzed and re-view of the literature. Results These were 5 male patients, aged between 26-37 years old, 3 cases were first diagnosed as KS, another 2 cases were diagnosed after antiviral therapy ( antiretroviral therapy, ART) , all occurred with the skin damage, followed by multiple tissue infiltration. 1 patient didn’ t received chemotherapy, after 6 months, dead due to hemorrhage of di-gestive tract. The other 4 patients were given chemotherapy, in which 1 patients' CD4+ cells was increased to normal levels after the treatment, all lesions disappeared during follow-up examination, and experienced long-term survival. The other 3 patients were given chemotherapy with doxorubicin liposome of 4 cycles, the skin, oral and eyelid lesions were significantly decreased, lung and gastrointestinal lesions disappeared, and CD4+ cells was increased, but not increased to the normal level. In 1 case of prolonged treatment, lesions increased again, after adjusting treatment, these symptoms were under control, the other 2 cases did not continue chemotherapy, monitoring condition revealed steady, is still under closely follow up. Conclusion KS is gen-erally combined with skin damage, and may be accompanied by multiple organ infiltration. Diagnosis of KS is not difficult, ac-tive treatment can decrease the size of lesions, but monitoring the possible complications is needed. If CD4+ cells is increased after the treatment, then the prognosis would be better, or even completely cured.