Early enteral nutrition support in patients with acute stroke induced cardio-cerebral syndrome

YAN Tao; WANG Shuo; LIU Jinhu

doi:10.3969/j.issn.1671-6450.2015.02.005

Abstract：Objective To investigate the relationship between early enteral nutrition support and acute stroke in-duced cardio-cerebral syndrome in short term. Methods From 2010 January to 2014 January, 100 acute stroke patients in the department of neurology were enrolled, symptom occurred less than 72 h, disease was confirmed by cranio-cerebral CT or MR. They were randomly divided into observation group and control group with 50 cases in each group, the observation group re-ceived early enteral nutrition support, the control group were given parenteral nutrition support, comparative analysis between the 2 groups of patients were performed before and after clinical treatment, nutritional index, immune index and complications were compared. Results In the observation group, the total efficiency is 92. 0%, which is higher than that of the control group 72. 0% (χ2 =6. 18, P =0. 016). After the first day treatment, the observation group’s hernoglobulin, total protein, albumin, prealbumin as nutritional index were gradually reduced, but no significant differences of these nutritional indexes were found at 10th and 21st day of treatment from 1st day ( P >0. 05);After the first day treatment, the control group’s nu-tritional indexes were gradually reduced, significant differences of these nutritional indexes were found at 10th and 21st day of treatment from 1st day ( P <0. 05);21 days after treatment, hemoglobin, total protein, albumin and other nutritional indica-tors’ change in the observation group were significantly different from the control group ( P <0. 05). After the first day treat-ment, the observation group’ s total lymphocyte count ( TLC) , IgA, IgG, IgM, C3 , C4 immune indexes were gradually re-duced,but no significant differences of these immune indexes were found at 10th and 21st day of treatment from 1st day( P >0. 05);After the first day treatment, control group’s immunological indexes were gradually reduced, significant differences of TLC, IgA, IgG, C3 were found at 10th and 21st day of treatment from 1st day ( P <0. 05); after 21 days’ treatment, the observation group’s TLC, IgA, IgG, C3 etc. immune index were significantly different from the control group ( P <0. 05). Infection occurred in 22 patients in the observation group in the course of treatment, 5 patients with hypoproteinemia, control group’ s infection occurred in 9 patients, 6 cases of bedsore, hypoproteinemia in 8 cases, the complication rate between the 2 groups revealed statistical differences (χ2 =4. 23, P =0. 039). Conclusion Early enteral nutrition can improve the nutri-tional status of acute stroke comprehensive syndrome patients with cardio-cerebral syndrome, is helpful for improving immunity and rehabilitation.