A retrospective analysis of red blood cell distribution width in old patients with chronic heart failure
SONG Jun?
WANG Deguo
CHEN Kun
WANG Ancai
LU Kebing
Abstract：Objective To investigate the relationship between red blood cell distribution width ( RDW) and the car-diac function in old patients with chronic heart failure( CHF) and to evaluate the prognostic value of RDW in CHF. Methods From 2008 June to 2011 December, retrospective analysis 368 cases of hospitalized elderly patients with CHF. Automatic blood cell analyzer measured patients' RDW,ELISA was used for the determination of plasma brain natriuretic protein( BNP) concentration, determination of left ventricular ejection fraction(LVEF) by echocardiography Simpson method. Correlation be-tween different indexes was analyzed by using linear correlation analysis method. Results According to NYHA classification, patients were divided into three groups, Class II heart failure group of 82 cases, 187 cases in class III group, class IV group of 99 cases, in each group, RDW and BNP concentration was significantly different, and significantly increased with the pro-gression in the order of class IV group> class III group> class II group ( F =10. 012,13. 582, P <0. 01); according to LVEF=45% as the cut-off point,patients were divided into LVEF decrease groups and LVEF retention group,former group's RDW and BNP were significantly higher than the latter group (RDW:16. 4% ± 1. 6% vs. 14. 2% ± 1. 5%, P <0. 01;BNP:643 ng/L ± 168 ng/L vs. 232 ng/L ± 113 ng/L);according to BNP levels, heart failure patients were divided into low, medi-um, and high BNP group, high BNP group's RDW (16. 2 ± 1. 4)% was significantly higher than that of medium (15. 2 ± 0. 9) %, and low level group (13. 7 ± 1. 1)% ( q =18. 2,45. 82, P <0. 01);correlation analysis showed RDW significant-ly positive correlated with BNP ( r =0. 323 8, P <0. 01), and negatively related with LVEF ( r = -0. 218, P <0. 01). Conclusion RDW was significantly increased in NYHA advanced class of the heart function, LVEF decreased and high BNP elderly patients, and was positively correlated with BNP and negatively correlated with LVEF, suggesting that RDW can be used as a convenient and useful auxiliary index assessment of the severity of heart failure in the elderly.
Keywords：Red blood cell distribution widthBrain natriuretic peptideHeart failureLeft ventricular ejection fraction
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 114-116,124 )