Significance of hepcidin in patients with rheumatoid arthritis
ZENG Ting
SONG Chaoying
SHI Dan
GU Kefeng
Abstract：Objective To detect the changes of the levels of rheumatoid arthritis ( RA) patients serum hepcidin (Hepc), and to explore its clinical significance .Methods From 2012 August to 2014 February, 72 patients with RA were selected as RA group , 54 cases with normal physical examination were enrolled as healthy control group .With the serum level of Hepc (5.86 ng/ml) as the limit of RA, they were divided into normal subgroups and the elevation subgroup .Inflammatory factor, hemoglobin (Hb),the level of Hepc and disease activity score 28(DAS28) were compared between the 2 groups of subjects, and to explore the correlation between clinical indexes and serum Hepc level in patients with RA .Results RA group's CRP, TNF alpha, IL-6, Hb and Hepc levels were significantly higher than that in healthy control group with statistical -ly significant difference ( t =6.445,3.293, 3.910,2.874,8.572, P <0.01);Hepc normal subgroup 's DAS28 scores, IL-6 levels were significantly lower than the Hepc elevation subgroup ( t =3.142,4.420, P <0.01); Hepc levels of patients in the RA group were positive correlated with disease activity score (DAS28) and rheumatoid factor (RF), IL-6 level ( r =0. 288, P <0.01;r =0.271, P =0.01;r =0.301, P =0.02).Conclusion The level of Hepc has closely relationship to in-flammatory status and disease activity in RA patients .
Keywords：ArthritisrheumatoidHepcidinHemoglobin
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 33-35 )