Association between serum macrophage migration inhibitory factor and macroangiopathy in patients with type 2 dia-betes mellitus
DU Xuexia
CHEN Baofeng
DENG Yun
WU Mingqing
CHEN Xiaolong
Abstract：Objective To investigate the relationship between the expression of macrophage migration inhibitory fac -tor ( MIF) and type 2 diabetes mellitus ( DM) complicated with macrovascular disease .Methods According to with or with-out occurrence of major vascular lesions , type 2 DM patients (126 cases) were divided into group A ( n =65, vascular le-sions) and group B ( n =61, there was no vascular lesions ), 60 healthy subjects over the same period were selected as the healthy control group ( group C ) .Using the high-resolution ultrasound to detect the carotid artery intima-media thickness (IMT), MIF, fasting blood glucose (FPG), glycosylated hemoglobin (HbA1c), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), triglycerol (TG) were detected by laboratory examination in these 186 ca-ses of the participants .Results Group A and B 's monitoring results ( except HDL-C) were higher than those in group C;group A's MIF, IMT, HbA1c, LDL-C and TG levels were higher than in the group B , HDL-C were lower than in group B, and the difference had statistical significance ( P <0.05, P <0.01); carotid artery mild stenosis were 22 cases in group A (33.85%), moderate of 32 cases (49.23%), 11 cases of severe (16.92%);the level of MIF was positively correlated with IMT ( r =0.977), FPG ( r =0.551), HbA1c( r =0.909), LDL C ( r =0.779), TG ( r =0.615) (all P <0.01), and negatively correlated with HDL-C levels ( r =-0.516, P <0.01).Conclusion The MIF level in type 2 DM patients in-creased significantly;type 2 DM patients with vascular lesions , their MIF level was closely related of the degree of vascular le-sions, and correlated with blood glucose and blood lipid;monitoring the level of MIF in patients with type 2 DM has a higher value for the prevention and control of large vascular disease .
Keywords：Macrophage migration factorType 2 diabetes mellitusMacrovascular disease
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 29-32,35 )