Clinical curative effect of pramipexole dopamine receptor agonist in the treatment of advanced Parkinson's disease
ZHU Aijun
TAN Shaoyun
ZHANG Shuangshuang
Abstract：Objective To investigate the therapeutic effect of pramipexole combined with Madopar in the treatment of advanced Parkinson 's disease ( PD) .Methods Ninty-three cases with advanced PD were randomly divided into control group (46 cases) and observation group (47 cases), control group was given Madopar treatment , observation group was given pramipexole combined with Madopar , Hamilton Depression Scale ( HAMD) , PD rating scale Part III ( UPDRS III) changes , adverse reactions between two groups were compared .Results The observation group's efficiency (72.34%), the total effec-tive rate (89.36%) was significantly higher than that of the control group (47.83%, 60.87%), the difference was statisti-cally significant ( P <0.05, P <0.01);at the 8th weeks, 12th weeks, the 2 groups'UPDRS III score were (20.12 ±5.31, 18.56 ±4.37) and (24.15 ±5.29, 21.54 ±4.35), HAMD score were (9.37 ±4.35, 7.07 ±4.63) and (13.51 ±4.32, 10.92 ±4.59), adverse reactions were 21.28%(10/47) and 54.35%(25/46), the observation group were significantly lo-wer than those of the control group ( P <0.05).Conclusion Pramipexole combined with Madopar could significantly im-prove the motor symptoms , alleviate depression , and improve the treatment effect .
Keywords：Parkinson 's diseasePramipexoleClinical efficacy
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 26-28 )