Analysis of the clinical effect and prognosis of combined intravenous and intra-arterial thrombolysis and mechanical thrombectomy for early-stage acute ecrebral infarction
TIAN Yu
WANG Jiajun
LI Baoyun
WAN Feng
Abstract：Objective To observe the therapeutic effect and prognosis of intra-arterial combined with intravenous thrombolysis and mechanical thrombectomy for the treatment of acute cerebral infarction .Methods From 2012 June to 2014 June, 70 patients who were diagnosed of acute cerebral infarction and intracranial vascular stenosis or occlusion were enrolled , according to the different thrombolytic method , they were divided into intra-arterial combined with intravenous thrombolytic group with (control group) 35 cases, mechanical thrombectomy group with (observation group) 35 cases.Before and after the treatment, the National Institutes of Health Stroke Scale (NIHSS) score, clinical efficacy and prognosis in the short-term and long-term were evaluated in these patients .Results The clinical efficacy of observation group was better than the control group (97.14%vs.80.0%,χ2=5.081, P <0.05);in the observation group, after 3 d and 14 d's treatment, NIHSS score was significantly decreased than before treatment ( t =5.667, t =5.850, P <0.05);3 d after treatment, in the control group, compared with before treatment, NIHSS score's difference was not statistically significant ( t =1.683, P >0.05), af-ter 14 d's treatment, NIHSS score was significantly lower than that of before treatment ( t =8.326, P <0.05);3 d's after treatment, 2 groups'difference was statistically significant ( t =3.767, P <0.05), after treatment, observation group's TIMI flow grade ≥2 was significantly more than the control group , acute vascular reo-cclusion was significantly lower than the con -trol group (χ2 =17.481,χ2 =10.403, P <0.01);after treatment, 2 groups'residual stenosis rate, within 24 h's symptomatic intracranial hemorrhage rate and 3-month mortality differences were not statistically significant (χ2 =3.188,χ2 =0.159,χ2 =0.348, P >0.05).Conclusion Mechanical thrombectomy for the treatment of patients with acute cerebral infarction is bet -ter than the effect of intraa-rterial combined with intravenous thrombolysis , it can improve the neurological function in the ear-lier time,and the long-term prognosis is good .
Keywords：Intra-arterial combined with intravenous thrombolysisMechanical thrombectomyCerebral infarctionacuteClinical efficacyPrognosis
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 20-22 )