Long-term follow up of applying of rhBNP in patients with AMI after primary percutaneous coronary intervention

CUI Lijie; LI Zhanquan; MIAO Zhilin; YUAN Long

doi:10.3969/j.issn.1671-6450.2015.01.004

Abstract：Objective To observe the long-term effect of intravenous recombinant human brain natriuretic peptide (rhBNP) on acute myocardial infarction (AMI) patients after percutaneous coronary intervention (PCI).Methods Ninty-eight cases of patients with AMI were randomly divided into rhBNP treatment group with 52 cases and normal saline control group with 46 cases.2 groups of patients were treated with drug treatment and PCI operation .Treatment group:intraoperative and postoperative intravenous application of rhBNP was used , according to the 1.5μg/kg loading dose of intravenous injection (>3 min), followed by 0.01μg? kg-1? min-1(for 48 h);control group:during PCI operation and post operation applica-tion of intravenous saline infusion .Plasma NT-proBNP before PCI in the 2 groups were tested.Long-term follow up of 2.5-3 years, major adverse cardiovascular events ( MACE) , cardiac function and plasma NT-proBNP changes were observed .Re-sults Followed up for 2.5-3 years, average of 2.7 years.The treatment group with 48 cases were completed the follow-up, 40 cases in the control group were completed the follow-up, the plasma NT-proBNP in treatment group was significantly lower than that of the control group [(971 ±89) pg/ml and (1644 ±106) pg/ml, t =0.275, P =0.04];SV, LVEF in the treat-ment group were higher than the control group [(46.2 ±4.2) ml and (50.1 ±6.7) ml, t =-1.870, P =0.03;(43.6 ± 2.2)%and (48.6 ±2.4)%, t =-1.896, P =0.04],LVEDD was lower than control group ( t =0.246, P =0.04);2 cases in the treatment group recurred of heart failure (4.2%), which is lower than that of the control group of 7 cases (17.5%) ( P =0.04).Conclusion It demonstrated tha the long-term follow up revealed that early application of rhBNP after PCI in AMI patients could significantly improve heart function .