Effects of trimetazidine on plasma levels of homocysteine, matrix metalloprotei nase-9 and vascular endothelial func-tion in elderly patients with unstable angina
XIAO Yue
ZHAO Deyou
ZHANG Yin
DO NG Ningchao
ZHAO Cuizhu
Abstract：Obj ective To investigate the levels of plasma homocysteine ( Hcy) levels, matrix metalloproteinase-9 (MMP-9) and the endothelial function after use the trimetazidine hydrochloride in treatment of elderly patients with unstable angina pectoris ( UA) .Methods Totally 150 cases with UA patients ( age≥60 years ) were randomly divided into control group (75 cases) and observation group (75 cases)by random number table,2 groups received nitrates, aspirin, statins, beta blockers and other conventional , the observation group added trimetazidine hydrochloride (20 mg, 3 times/d), 2 groups re-ceived 1 month of treatment , level of plasma Hcy , MMP-9 and endothelial cells function before and after treatment were test-ed.Results There were no significant difference of Hcy , MMP-9 and endothelial function between the 2 groups before treat-ment ( P >0.05);after 1 month treatment, 2 groups'Hcy, MMP-9, endothelin-1 (ET-1) and von Willebrand factor (vWF) were significantly decreased ( P <0.05), nitric oxide (NO) and brachial artery flow mediated endothelial dependent dilata-tion rate (FMD) were significantly increased ( P <0.05).The observation group was better than the control group ( P <0.05).Conclusion Trimetazidine hydrochloride can improve endothelial function by reducing Hcy , ET1-and vWF levels, and increasing NO levels , and reduced MMP-9 level to prevent of myocardial remodeling .
Keywords：Trimetazidine hydrochlorideAngina pectorisunstableHomocysteineMetalloproteinase-9Endothelial function
Publication Date：2015-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 10-12 )