Effects of glutamine and lactose free formula feeding on nutritional status, immune function and gastrointestinal hor-mones of premature infant with necrotizing enterocolitis
XIAO Yong
HUANG Ruiwen
LI Qiang
YANG Hui
YE Hongqiu
Abstract：Objective To investigate the effects of glutamine and lactose free formula feeding on premature infants with necrotizing enterocolitis nutritional status , immune function and gastrointestinal hormone .Methods Sixty premature in-fant with necrotizing enterocolitis were enrolled in the study , they were randomly divided into observation group and control group with 30 cases in each group , the observation group received glutamine and lactose free formula feeding , the control group were received glutamine and breastfeeding , children nutrition status , immune function , gastrointestinal hormone were compared between the 2 groups..Results (1) nutritional status:4 weeks after treatment, albumin, preprotein content in the observation group were significantly higher than those of control group [(112.31 ±15.23) g/L vs.(103.19 ±13.75) g/L, (41.48 ±5.61)g/L vs.(32.58 ±4.46) g/L, P <0.05].(2)Immune function:2 weeks after treatment, CD4+T cells ratio and IgA, IgG, IgM in the observation group were significantly higher than those of control group [(38.11 ±3.91)% vs. (32.52 ±4.84)%, (13.14 ±1.45) g/L vs.(10.12 ±0.73) g/L,(2.86 ±0.33) g/L vs.(1.77 ±0.21) g/L,(1.43 ± 0.19) g/L vs.(1.02 ±0.13) g/L, P <0.05];CD8+T cells ratio was significantly lower than that control group [(21.95 ± 3.13)%vs.(27.51 ±3.76)%, P <0.05].(3) Guthormone levels: gastrin and motilin content in the observation group were significantly higher than those of control group [(292.45 ±35.82) pg/ml vs.(231.38 ±29.14) pg/ml,(121.85 ± 16.34) pg/ml vs.(90.45 ±11.34) pg/ml, P <0.05].Conclusion Glutamine and lactose free formula feeding is helpful to improve the nutritional status , immune function , improve the gastrointestinal tract hormone content , and improve therapeu-tic effect.
Keywords：Enterocolitis necrotizingGlutamineLactose free formula milkNutritional statusImmune functionGastrointestinal hormone
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 1272-1274 )