Therapeutic effect and safety of BCG polysaccharide nucleic acid on nongonococcal urethritis
ZHOU Liangyi
LI Xue-feng
MA Jin’ e
ZHAO Yong
JIN Qiang
Abstract：Objective To observe the therapeutic effect and safety of BCG polysaccharides nucleic acid on treatment of non gonococcal urethritis .Methods Fifty-seven patients with nongonococcal urethritis were randomly divided into the ob -servation group with 31 cases and control group with 26 cases.The control group were treated with azithromycin in 0.9%sodium chloride injection or 5%glucose injection intravenous infusion of 500 ml to 60 min, 1 /d, period of treatment is 7-10 d;the observation group based on the treatment as control group , also received BCG polysaccharide and nucleic acid intramuscular injection, 1 ml/time, 3 times a week, lasted for 3 weeks;the clinical efficacy, pathogenic effect, recurrence and adverse re-action were observed and compared between the 2 groups.Results Observation group’s cure rate is 90.3% (28/31), the total efficiency was 96.8%(30/32), the recurrence rate is 16.1% (5/31); in the control group, the cure rate is 65.4%(17/26), the total efficiency of 73.1%(19/26), the recurrence rate is 34.6%(9/26), significant differences were found between the 2 group ( P <0.05).After the treatment, the pathogen clearance rate was 87.17%(163/187) in the observa-tion group;the pathogen clearance rate in the control group was 82.47%(80/97), no significant difference were found (P >0.05).The observation group revealed nausea , vomiting, mild stomach discomfort symptoms in 2 cases, intramuscular injec-tion of redness chills in 1 cases, 1 cases of abdominal pain, vertigo; control group had 3 cases of nausea, vomiting, mild stomach discomfort symptoms, abdominal pain, the body from the wheal symptoms in 2 cases, the adverse reaction rate be-tween the two groups had no significant difference (12.9% vs.19.2%, P >0.05).Conclusion It demonstrated that the BCG polysaccharide nucleic acid combined with azithromycin is safe and effective in treating non gonococcal urethritis with good safety , it can effectively shorten the course of disease and prevent recurrence , and is worth the clinical promotion .
Keywords：BCG polysaccharide nucleic acidUrethritisnongonococcalTherapeutic effectSafety
Publication Date：2014-01-01
Pages：3( 1266-1267,1271 )