The expression and clinical significance of the expression of TAK1 in breast cancer
LI Quanyuan
WEI Jian
YAN Liqin
WANG Qun
Abstract：Objective To investigate the expression and its clinical significance of transforming growth factor beta ac -tivated kinase-1 (TAK1) in breast cancer tissues.Methods From 2011 August to 2013 February, 180 cases of breast speci-mens from department of pathology were randomly selected for further investigation , which included 80 cases of normal breast tissues, 60 cases of fibroadenoma of breast tissue , 40 cases of breast carcinoma , these cases were underwent immunohisto-chemical analysis , the expression of TAK1 in breast cancer , and the pathological characteristics were analyzed .Results Nor-mal breast tissue cells arranged in an orderly manner , cell morphological integrity; fibroadenoma of breast tissue showed a large number of glandular cavity or cords; breast cancer shown as cancer tissues cord or island like distribution , invasive growth in interstitial.The positive expression of TAK1 in the 3 group rate was 7.50%, 46.67%and 70.00%, respectively, there were statistically significant differences among groups ( P <0.05).The positive expression rate of TAK1 in different ax-illary lymph node metastasis and clinical staging revealed significant differences ( P <0.05), no significant differences were found in different age, BMI and pathological types of breast cancer ( P >0.05).Conclusion TAK1 showed high positive expression in breast cancer tissues , and positive correlated with pathological metastasis and clinical stage , it may be one of the factors leading to the genesis and development of breast cancer .
Keywords：Transforming growth factor activated kinase-1Breast cancer
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 1254-1256 )