Clinical observation of hyperbaric oxygen combined with gastrodin and mecobalamin on diabetic peripheral neuropa-thy

TIAN Li; YANG Liu; PEI Jiyan; YE Chunfang; LIU Zhiwei; MENG Xianjie; LI Ying

doi:10.3969/j.issn.1671-6450.2014.12.010

Abstract：Objective To investigate the effect of hyperbaric oxygen combined with gastrodin and mecobalamin on diabetic peripheral neuropathy .Methods Collected type 2 diabetic patients with peripheral neuropathy in 72 cases,they were randomly divided into 2 groups, 36 cases in each group .All patients were treated with oral antidiabetic drugs or subcutaneous injection of insulin hypoglycemic therapy , the control group was given gastrodin intravenous infusion of 6 ml and mecobalamin 500 μg intravenous infusion , the treatment group besides the same as control group , also received hyperbaric oxygen ( HBO) therapy with oxygen pressure of 0.2 MPa, 30 min with 5 min inhalation of air, repeated 2 times, the total oxygen time 60 min, once a day.The 2 groups were treated for 2 weeks, the clinical effect after treatment , the sensory nerve conduction velocity (SNCV) and motor nerve conduction velocity (MNCV) were compared.Results The clinical therapeutic effect of the treat-ment group was significantly better than the control group (86.2% vs.63.9%),the difference was statistically significant (P <0.05).Compared with before treatment, the treatment group of common peroneal nerve, tibial nerve’s SNCV and MNCV and sural nerve’s SNCV were significantly increased ( P <0.01); the control group’s common peroneal nerve’s MNCV increased obviously ( P <0.01), other nerve conduction velocity revealed no significant changes ( P >0.05).After treatment, between the 2 groups, the treatment group common peroneal nerve and posterior tibial nerve and sural nerve ’ s SNCV were lower than those in the control group increased ( P <0.01), but no significant difference was found in MNCV (P >0.05).Conclusion Hyperbaric oxygen combined with gastrodin and mecobalamin revealed good effect on diabetic pe -ripheral neuropathy , its worthy of clinical application .