Effect of BiPAP on central aortic pressure and the NT-proBNP in patients with different degree of OSAHS
WANG Na
LIU Hualing
LI Ping
ZHANG Yan
Abstract：Objective To observe the effect of bi level positive airway pressure ( BiPAP) on central arterial pressure , N-terminal pro brain natriuretic peptide (NT-proBNP) in patients with different severity of obstructive sleep apnea syndrome (OSAHS).Methods One hundred and seventy-two cases of patients with OSAHS (observation group) were enrolled, ac-cording to the diagnostic standard of OSAHS and the severity of the disease , they were divided into 3 subgroups: mild sub-group with 58 cases, moderate subgroup with 59 cases, severe subgroup with 55 cases, 60 normal people in the same period were selected as healthy control group .Comparative analysis of clinical characteristics were performed in each group ;the pa-tients in the observation group were treated with BiPAP , after 30 days, the changes of the level of central systolic pressure , diastolic pressure and NT center proBNP were observed;and the relationship between center systolic pressure , center diastolic pressure, NT /proBNP and apnea hypopnea index (AHI) were analyzed.Results (1) Compared with healthy controls , OS-AHS mild sub group’s body mass index (BMI),fasting blood glucose (FBG), glycosylated hemoglobin (HbA1c), total cho-lesterol ( TC) , three glycerol ( TG) , low density lipoprotein ( HDL-C) , high density lipoprotein ( LDL-C) revealed no signifi-cant changes ( P >0.05);moderate subgroup and severe subgroup ’s BMI, Glu, HbA1c, TC, TG, LDL-C were increased, HDL-C were decreased ( P <0.05), the differences between each subgroup also have statistical significance ( P <0.05). (2) 30 d after BiPAP treatment, central arterial pressure and NT-proBNP in each subgroup of the observation group were de-creased compared with healthy controls group and before treatment ( P <0.05), and among these subgroups , after treatment, differences also have statistical significance ( P <0.05).(3) Central systolic pressure, center diastolic pressure, NT-proB-NP in the observation group was positively correlated with AHI ( r =0.783, r =0.634, r =0.348, P <0.05).Conclusion Through lower the central arterial pressure , NT-proBNP level in patients with OSAHS , BiPAP reduce the target organ damage;improve the prognosis .
Keywords：Bi level positive airway pressure ventilationObstructive sleep apnea syndromeCentral aortic pressureN-terminal pro brain natriuretic peptide
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1240-1243 )