Study on the correlation between cerebral small vessel disease induced leukoaraiosis and cognitive impairment

YUN Qiang; JIANG Mingfang; SU Ning; ZHANG Xiaojun; ZHANG Ruijian

doi:10.3969/j.issn.1671-6450.2014.12.003

Abstract：Objective To evaluate correlation between cerebral small vessel disease ( CSVD) induced leukoaraiosis and cognitive impairment .Methods Collected outpatient and inpatient CSVD patients ,130 cases complicated with WML were chosen as observation group;Selected 122 health volunteers without neurological and psychiatric disorders as healthy control group.MR brain scans were carried out, according to age-related white matter changes rating scale ( ARWMCRs) ,observa-tion group was divided into 42 cases of mild subgroup, 51 cases of moderate subgroup, 37 cases of severe subgroup .Use Mini-Mental State Examination ( MMSE) and Montreal Cognitive Scale ( MoCA) screening assessment of cognitive function, analyze the relationship between leukoaraiosis and cognitive dysfunction .Results MoCA scores showed that the observation group in the visual space and implementation capacity, attention, language ability, abstract ability was significantly lower than the healthy control group ( P <0.01), whereas in naming ability, disorientation and memory latency, the observation group score was lower than the healthy control group ( P <0.05).Compared with the healthy control group, the risk of the combined leu-koaraiosis CSVD patients with vascular cognitive impairment was significantly higher (RR=8.2, P <0.01), but also there was strong correlation between white matter lesions ( WML) and cognitive impairment ( OR=6.059, 95% CI=2.301 -18.728, P <0.01).Conclusion CSVD induced leukoaraiosis is correlated with cognitive dysfunction ,by detecting white matter lesions in patients with early screening of patients had mild cognitive impairment, prevention of vascular cognitive im-pairment .