Clinical observation the therapeutic effect of Tongxinluo capsule on patients with angina pectoris and depression

LI Na; GU Xingjian; ZHENG Xueyang; WU Zonggui

doi:10.3969/j.issn.1671-6450.2014.11.021

Abstract：Objective To investigate the effect of Tongxinluo capsule on improvement of angina pectoris of coronary heart disease patients with depression symptoms and quality of life of depressive state .Methods Seventy-two cases of patients with angina pectoris of coronary heart disease accompanied with depression were randomly divided into 2 groups, 36 cases in each group.The control group was given conventional treatment , the observation group based on the conventional treatment , also added Tongxinluo capsule treatment, treatment for 8 weeks, before and after the treatment , using the Seattle Angina Questionnaire ( SAQ) and Hamilton Depression Scale ( HAMD) to evaluate patients ’ health related quality of life and depres-sion state.Results Compared with before treatment , patients in the observation group after treatment , angina pectoris condi-tion, the attack of angina pectoris , treatment satisfaction and disease cognitive level were significantly improved , the control group’s attack of angina pectoris , treatment satisfaction, disease recognition degree were improved ( P <0.05 or P <0.01). Angina pectoris condition and angina pectoris improvement in the observation group was significant difference from the control group ( P <0.01).Both of the 2 groups’ HAMD scores were significantly decreased than that before treatment ( P <0.01), and the observation group decreased more significantly than in the control group ( P <0.01).The total effective rate of the 2 group were 77.78%and 36.11%, with significant difference ( P <0.01).Conclusion The quality of life and de-pression condition can be improved with Tongxinluo capsule combined with routine treatment for patients with angina pectoris of coronary heart disease and depression symptoms .