Effect of 25(OH) D3 on cardiac structure and function in diabetic patients with maintenance hemodialysis
HAN Ying
GONG Yanhui
WANG Ruixin
YAN Yuehong
JIANG Yanqiong
ZHANG Fengling
HUANG Ying
HUANG Aiqun
ZHANG Shaofeng
Abstract：Objective To investigate the effect of 25( OH) D3 in the treatment of diabetic nephropathy ( DN) with maintained hemodialysis patients ’ cardiac structure and function .Methods Forty-one patients undergoing 25 ( OH) D3 treat-ment for DN maintenance hemodialysis (0.25 μg orally,once a day) for 24 weeks, observe and compare before and after treatment, serum 25 (OH) D3, 25 (OH) D2, brain natriuretic peptide (BNP), parathyroid hormone (iPTH),Ca2+level, QT dispersion/corrected QT dispersion ( QTd/QTcd ) , left atrial diameter ( LAD ) , left ventricular end diastolic diameter (LVEDD), left ventricular posterior wall thickness (LVPWDT), diastolic ventricular septal diastolic thickness (IVSDT), left ventricular ejection fraction ( LVEF) and diastolic early and late diastolic mitral valve maximum blood flow velocity ratio (E/A).Results After treatment, blood 25(OH)D3 and blood Ca2+levels increased obviously increased , BNP, iPTH levels were decreased , QTd and QTcd significantly shortened , LVEDD, LVPWDT, LAD, IVSDT, LVEF, E/A were obviously im-proved ( P <0.01, P <0.05);25 ( OH) D3 was negatively correlated with blood BNP , iPTH, QTd, QTcd, LAD, LVP-WDT, IVSDT, LVEDD( r =-0.39, r =-0.49 r =-0.65, r =-0.66, r =-0.48, r =-0.49, r =-0.50, r =-0.52, P <0.05, P <0.01), 25(OH)D3 was positively correlated with LVEF and E/A ( r =0.47, r =0.46, P <0.01).Conclusion It demonstrated that the 25 (OH) D3 could improve the cardiac structure and function of DN mainte-nance hemodialysis patients , reduce ventricular repolarization asynchrony and instability .
Keywords：Diabetes nephropathy25(OH)D3Maintenance hemodialysisCardiac stractureCardiac function
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 1134-1136 )