Association of the level of serum pro-hepcidin and rheumatoid arthritis
ZENG Ting
SONG Chaoying
LU Jingzhong
Abstract：Objective To detect the level of serum pro-hepcidin levels in the rheumatoid arthritis ( RA) patients, and to explore its correlation with disease activity and anemia .Methods Fifty cases of RA patients as RA group , 50 healthy people as healthy control group , disease activity in patients with RA was assessed by disease activity score table 28 (DAS28). Detected the participants of hemoglobin , serum iron, ferritin, iron binding, erythrocyte sedimentation rate (ESR), C-reactive protein ( CRP) , titers of rheumatoid factor and anti-cyclic citrullinated peptide antibody titer , serum pro-hepcidin level , and compared the difference between groups .Results The hemoglobin , serum iron RA group was significantly lower than that of healthy control group, while ESR, CRP, anti CCP antibody and rheumatoid factor , ferritin, pro hepcidin levels were signifi-cantly higher than that in healthy control group ( P <0.01), and RA active sub group (DAS28>5.1)’ s serum ferritin, CRP, ESR, pro-hepcidin levels were significantly higher than those of inactive sub group (DAS28≤5.1) ( P <0.05).Pro-hepcidin levels and RA disease activity index such as DAS 28, ESR and CRP, the number of joint pains , ferritin were positive-ly correlated ( r =0.596, r =0.406, r =0.502, r =0.567, r =0.420, P <0.05, P <0.01).Serum pro-hepcidin level in RA patients with and without anemia revealed no obvious difference .Conclusion RA patients ’ serum pro-hepcidin level can reflect disease activity , pro-hepcidin is expected as a biomarker for disease activity in patients with RA .
Keywords：Rheumatoid arthritisPro-hepcidinAnemia
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1130-1133 )