Clinical observation of atorvastatin combined with Qianggu capsules in the elder patients with type 2 diabetic osteopo- rosis

LUO Juan; QIN Aiping; ZHAO Xinlan; CHEN Kai; LI Wenjing

doi:10.3969/j.issn.1671-6450.2014.10.004

Abstract：Objective To observe the curative effect of atorvastatin combined with Qianggu capsules in the treatment ofelderlypatientswithtype2diabeticosteoporosis.Methods 100casesofelderlypatientswithtype2diabeticosteoporosis were randomly divided into 2 groups, 50 cases in each group.The treatment group received oral atorvastatin and Qianggu cap-sules;the control group was given orally Qianggu capsules, 2 groups were treated with combined use of calcium carbonate Vi-tamin D3 , both groups were taking medication for 6 months.Observed the clinical curative effect of the pain scores and the bone density evaluation before and after treatment (BMD) condition in the 2 groups.Results Compared with pre and post treatment, fasting plasma glucose(FPG),postprandial 2 h blood glucose(2 hPG),HbA1c in the 2 groups were improved, the difference was statistically significant ( P <0.05), and BMI showed no significant change ( P >0.05), the difference be-tween the 2 groups has no statistical significance ( P >0.05).Compared with before treatment ,2 groups’ pain scores were decreased [(7.96 ±2.73) vs.(3.68 ±1.76), (7.89 ±2.90) vs.(5.26 ±1.65), P <0.01],the treatment group de-creased more obvious than control group ( P <0.05);compared with before treatment, bone density were improved in treat-ment group( P <0.05), while no significant improvement were found in control group ( P >0.05).Compared with the con-trol group, the treatment group’s pain scores, lumbar spine and femoral neck BMD were improved obviously , the difference was statistically significant ( P <0.05).Conclusion Atorvastatin has a synergistic effect on Qianggu capsules in the treat-ment of elderly patients with type 2 diabetic osteoporosis therapy .