Clinical study of recombinant human brain natriuretic peptide treating dilated cardiomyopathy refractory heart fai-lure
YIN Quanzhong
CUI Junyou
ZHENG Ruolong
GAO Chunheng
YI Guibin
LI Weizhang
CAI Jing
QIAN Huidong
CHEN Xinjun
LU Ye
ZHANG Hua
Abstract：Objective To explore the clinical effects of recombinant human brain natriuretic peptide (rh-BNP) in thetreatment of decompensated heart failure in patients with dilated cardiomyopathy .Methods A total of 50 patients with dilatedcardiomyopathy who suffered from decompensated heart failure were randomly divided into rh -BNP treatment group and milrinonecontrol group, 25 cases in each group.Both groups were treated with conventional drugs against heart failure .Treatmentgroup was injected rh-BNP while control group given intravenous drip of milrinone .Heart rates, mean arterial pressures, urinevolume, heart functions, plasma BNP and clinical effects of 2 groups before and after treatment were observed .Results Comparedwith before treatment in one week , the total effective rate of treatment group(88.0%)was notably higher than those ofcontrol group(64.0%),the difference was statistically significant ( P <0.05).After the treament, heart rates of treatmentgroupsconspicuously decreased in 24 hours, Treatment group were significantly lower heart rate ( P <0.05), mean arterialpressure was significantly lower ( P <0.05), significantly increased urine volume ( P <0.01).whereas urine volume distinctlyincreased.Besides, the left ventricular ejection fraction (LVEF) in one week and plasma BNP in 24 hours of 2 groupswere obviously improved after treatment , whereas the increased LVEF and the decreased plasma BNP in treatment group weresignificantly notable than those in control group ( P <0.01, P <0.05).Conclusion rh-BNP, being capable of amelioratingheart failure symptoms of patients evidently , has marked therapeutic effects in the treatment of decompensated heart failure inpatients with dilated cardiomyopathy .
Keywords：Recombinant human brain natriuretic peptideDilated cardiomyopathyHeart failurerefractoryClinicaleffects
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 995-997 )