Effects of pitavastatin on inflammatory factors and the role of oxidative stress in a rat model of myocardial ischemia-reperfusion
YOU Yang
QI Guoqing
XIA Yue
FENG Qian
ZHANG Qingwen
YANG Zhiyu
Abstract：Objective To explore the effects of pitavastain on inflammatory factors ( IL-6,IL-26,TNF-α) and T-SOD and cardiac infarct area in a rat model of myocardial ischemia-reperfusion , which will provide a theoretical basis for pitavastain clinical application in myocardial ischemia-reperfusion .Methods A total of 42 male SD rats were randomly assigned to three groups:Sham group , control group ( I/R group ) and experimental group ( Statin group ) .In Sham group and control group , 2ml saline were irrigated into stomach daily for 4 weeks, 0.42mg/kg pitavastain dissolved in 2ml saline were given in experi-mental group.In surgery,we weared line under the coronary artery without ligation in Sham group , and ligated the line for 30 minutes and then release it for 2 hours in I/R group and Statin group.The levels of IL-6,IL-26,TNF-αand CK-MB were dis-cerned after operation.Results Compared with I/R group,Statin group significantly reduced infarct size (AN/AAR)( P <0.01).The levels of IL-6,IL-26,TNF-αand CK-MB in control group and experimental group elevated significantly compared with Sham group( P <0.01), but lower when comes to T-SOD content( P <0.05).The levels of IL-6,IL-26,TNF-αand CK-MB in I/R group were significantly higher than Statin group ( P <00.5 ) .Conclusion Pitavastatin could inhibit the re -lease of inflammatory mediators ang increase antioxidant capacity .It took a positive role in ischemia-reperfusion myocardial in-jury prevention .
Keywords：Myocardial ischemia-reperfusion injuryPitavastatinInflammatory factorsCardiac infarct areaRats
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 932-935 )