Expression of Bax and Bcl-2 in mice with myocardial infarction
CHENG Lin
XIA Hao
Abstract：Objective To determine the expression of apoptotic protein Bax and Bcl-2 in heart of mice after myocar-dial infarction.Methods Forty male C57BL/6 mice were randomly divided into 2 groups: the control group (10 rats) and experimental group (30 rats), in the experimental group, left anterior descending coronary artery was ligated to establish the model of myocardial infarction , in the control group , no ligation were performed in the anterior descending coronary artery .Af-ter 4 weeks, the 2 groups of mice's myocardial material were taken , western blot method were used for detection of Bax and Bcl-2 protein expression differences in the heart .Results 4 weeks after operation , the survival rate of mice in the experimen-tal group was 53.3%(16/30), the control group was 100% (10/10).Bax and Bcl-2 in the control group had the expres-sion,in the experimental group ,expression increased gradually in area far from myocardial infarcted ( N) ,the surrounding area of myocardial infarction (B), infarction area (I) ( P <0.05), and the B zone, I zone Bax/Bcl-2 ratio is higher than that of N and control group ( P <0.05).Conclusion The high expression of Bax and Bcl-2 in heart after myocardial infarction may suggest that apoptosis plays an important role in later period of cardiac reconstruction after myocardial infarction .
Keywords：Myocardial infarctionApoptosisBaxBcl-2Mice
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 929-931 )