The clinical effect of Shugan tablet on obesity type 2 mellitus gastro-paresis patients

ZHANG Hua; FENG Hong; ZHANG Lixin

doi:10.3969/j.issn.1671-6450.2014.09.014

Abstract：Objective To explore the clinical effect of Shugan Tablet adjuvant treatment on obese type 2 diabetic gas-tro-paresis patients .Methods From 2012 January to 2013 December , in our hospital , 120 obesity type 2 diabetic gastro-pare sis patients were enrolled , they were randomly divided into 2 groups, the observation group of 65 cases, and 55 cases in the control group, the 2 groups were given conventional therapy , the observation group adds the Shugan Tablets 4 tablets, 2 times every day;the control group did not take any medicine .The 2 groups were treated for 30 days.At the end of the treatment , clinical symptoms score, plasma leptin, glucagon like peptide-1 (GLP-1), gastric emptying rate, level of electrogastrogram were compared between the two groups .Results The clinical symptoms score before and after treatment in the observation group had statistical significant differences , the differences of these index between observation and control group after treatment also significant ( P <0.05).Total effective rate of observation group is higher than that of the control group (90.77% vs. 29.09%, P <0.05).The serum leptin level of observation group after treatment were decreased obviously than before treat -ment and control group after treatment ( P <0.05), no change were found in GLP-1 level before and after treatment ( P <0.05);compared with before treatment , GLP-1 and leptin level had no statistical significance in the control group after treat-ment ( P >0.05).The stomach emptying rate group, average amplitude of electrogastrogram display in the observation group after treatment increased than before treatment and control group after treatment , the differences were statistically significant (P <0.05).Conclusion Shugan tablets could reduce the leptin levels in diabetic patients , thus affecting the gastric emp-tying, clinical curative effect is good , and provide clinical basis for the treatment of obesity and type 2 diabetes mellitus gastro-paresis patients .