The relationship between serum adropin levels and disease severity of cerebral ischemic stroke
HOU Yongge
QIN Shijie
WANG Jing
WANG Jungang
LIU Chunsheng
Abstract：Objective To investigate the correlation between changes of cerebral ischemic stroke serum Adropin level and the severity of the disease .Methods 120 patients with cerebral ischemic stroke were enrolled , according to the USA Na-tional Institutes of Health Scale (NIHSS) stroke score to assess the severity of the patient's condition, patients were divided in-to 3 subgroups:mild sub group (NIHSS<4) with 44 cases, moderate subgroup (NIHSS 4-15) with 40 cases and severe subgroup (NIHSS>15) with 36 cases.Another 30 healthy subjects were selected as control group .Adsorption analysis by en-zyme linked immunosorbent assay ( ELISA) to detect the level of serum Adropin , serum LDL-C, HDL-C, TG and TC levels detection were performed by automatic biochemistry analyzer;using Pearson test methods to analyze serum Adropin level and correlation with NIHSS score.Results Compared with the control group, cerebral ischemic stroke patients’ serum Adropin, HDL-C level decreased significantly ( t =5.976, t =8.845, P <0.01), serum TC, TG and LDL-C were obviously higher than control group ( t =10.195, t =15.331, t =10.296, P <0.01).Along with the NIHSS score increased, the serum Adropin levels decreased gradually ( F =518.547, P <0.01).Correlation analysis showed that there was a significant nega-tive correlation of serum Adropin level and NIHSS score ( R =-0.958, P =0.000).Conclusion Changes of serum Adropin participate in the occurrence and development of ischemic stroke , it can evaluate the clinical severity of patients with ischemic stroke .
Keywords：Cerebral strokeischemicSerum AdropinUSA NIH Stroke ScaleCorrelation
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 897-899 )